Expressions of Interest

AeMAT welcomes expressions of interest from postdoctoral researchers with an excellent track record to apply jointly with a research supervisor from AeMAT to the European Commission Marie Sklodowska-Curie Actions (MSCA) Individual Fellowship scheme. These fellowships offer individuals the opportunity to enhance their career development and prospects through advanced training, international and intersectoral mobility. If successful, the fellowship will provide a generous salary and an allocation for research and training costs.

Selected candidates will be provided with both nominated academic and administrative support with regards to proposal development.

Candidates interested in participate with AeMAT should:

Candidates are required to read carefully the MSCA IF Guide for Applicants to ascertain eligibility, especially with regard to the mobility rules for each scheme, and then express their interest no later than 30th Jun 2020 (17:00h), by providing:

  • Applicant’s full updated CV (max. 2 pages plus full list of publications)
  • A Research proposal summary (max. 2 pages) related to the offered projects (please include the reference of the project)
  • A letter of interest with the motivation to join the research group (max. 1 page)

In case of interest, send this information to aemat@usc.es before the deathline 30/06/2020 (17:00h, Madrid Time).

Candidates can check the projects list above:

Design of new efficient lubricants based in Nanomaterials

Project Code NAFOMAT_1
Host Researcher Josefa Fernández Pérez
Contact email (for inquiries) Josefa.fernandez@usc.es
Research Group NAFOMAT
Summary
The laboratory of Thermophysical and Tribological Properties of the Nanomaterials, Photonics and Soft Matter Group is expert in the characterization and design of lubricants for the production, storage and efficient use of energyThe candidate will work in the design and characterization of new nanolubricants formed by the addition of new nanomaterials in base oils or in fully formulated lubricants. Hybrid nanomaterials or hybrid additives composed by nanoparticles and ionic liquids will be also considered. For this purpose, the candidate will select, synthetize, and characterize nanoadditives to obtain stable dispersions of nanoadditives in some synthetic lubricant bases, through chemical surface modification and/or the use of ionic liquids as dispersants. Thermophysical characterization (density, dynamic viscosity, viscosity index, surface tension, contact angle) of nanolubricants and the evaluation of the tribological behavior (friction and wear) of the designed nanolubricants in boundary, mixed and elastahydrodynamic lubrication regimes should be also evaluated.The ultimate goal of the present fundamental study is to contribute to provide knowledge on lubricants that can be used in real applications improving the currently used lubricant performance, as well as proposing high performance environmentally friendly lubricants for wind energy and electrical cars, among other applications.

 

Development of new nanotools and validation methodologies in the search of an efficient diagnosis and treatment of early atherosclerotic events

Project Code GFCP_1
Host Researcher Pablo Taboada Antelo
Contact email (for inquiries) Pablo.taboada@usc.es
Research Group GFCP
Summary
The candidate will work on the development of new nanotools and validation methodologies in the search of an efficient diagnosis and treatment of early atherosclerotic events and areas of vulnerable atherosclerotic plaque associated to acute cardiovasculare accidents. To achieve this goal, on a first stage new nanovehicles with simultaneous therapeutic and imaging capabilities based on membranes of cells that actively participate in the process of early atherogenesis will be designed. These “artificial nanocells” should keep intact their ability to target and infiltrate specific inflammed vascular tissue at early stages of the atherosclerotic cascade, maintaining their homotypic. On a second stage, new microfluidic-based “artery-on-a-chip” devices will be desgined and used to i) allow a more accurate view of the underlying inflammatory mechanisms of vascular endothelium and the formation of the atherosclerotic plaque; ii) to achieve a more precise evaluation and validation of the therapeutic activity of the designed nanovehicles; iii) to  increase the correlation between the data obtained from in vitro and in vivo tests with the ultimate aim of minimizing the need for the latter. This research constitutes a step forward in the direction of personalized medicine in the field of cardiovascular diseases, in which atherosclerosis is the main underlying factor.

 

New vaccination and immunoregulatory approximation against viral infections

Project Code GFCP_2
Host Researcher Pablo Taboada Antelo
Contact email (for inquiries) Pablo.taboada@usc.es
Research Group GFCP
Summary
The candidate will work on a new vaccination and immunoregulatory approximation against viral infections based on the design of new nanotherapeutics able to target and control the release of encapsulated messenger RNA (mRNA) into dendritic cells (DCs) in order to estimulate DCs antigen presentation and, subsequently, exploit their capability to target and activate T-cells. The proposal focused on the developement of a nanovaccine engineered by using a coating of proteins and membrane components extracted from non-prestimulated and pre-stimulated (for costimulatory marker expression) DCs themselves onto the surface of polymeric nanobubbles and/or lipid nanoparticles encapsulating the designed mRNA sequences (designed to achieve higgh levels of antigen presentation in MHCI and MHCII-complexes) and adjuvants, if required, to generate biomimetic synthetic dendritic-like nanocells (DNCs). By making use of specific and homotypic targeting (by fusing the cell-based coating with specific ligands to DCs), DNCs will target natural DCs for their passive or active payload release (for example, using ultrasound (US)-based stimulus providing spatiotemporal control). Extensive mRNA-induced intracellular antigen production and presentation will serve to initiate a strong immune response cascade, that is, facilitating DC maturation, migration, interaction and activation of naïve T-cells. This research constitutes a step forward in the direction of personalized vaccination and in the search of controlled and extensive immuno-responses against viral infections.

 

Development of hierarchical porous ceramic-based materials for pollutants

Project Code GFCP_3
Host Researcher Pablo Taboada Antelo
Contact email (for inquiries) Pablo.taboada@usc.es
Research Group GFCP
Summary
The candidate will work on the development of hierarchical porous ceramic-based materials for pollutants (metal ions, dyes, drugs, etc) extraction and degradation from aqueous environments. To build the designed nanostructures with different ranges of porosity, two different approaches will be followed: i) the combination of 3D-printing and Pickering emulsion/foam templating using metallic organic frameworks (MOFs) as the stabilizing nanoparticles, ii) the combination of 3D printing and a complete MOF-based surface coating post-functionalization strategy. The combination of the different hierarchachy levels of the developed nanostructures and the affinity and catalytic properties of selected MOF NPs would be then exploited in order to provide superior levels of pollutant reomoval and degradation, whilst ensuring long-life and operation of the developed complex materialls under stirred-tank and flow-through column operation conditions for water decontamination.

 

Mathematical and experimental modelling of molecular mechanisms of neurodegenerative pathogenicity

Project Code GFCP_4
Host Researcher Pablo Taboada Antelo
Contact email (for inquiries) Pablo.taboada@usc.es
Research Group GFCP
Summary
The candidate will work on mathematical and experimental modelling of molecular mechanisms of neurodegenerative pathogenicity with the aim of  developing new and complementary methodologies for High Throughput Screening (HTS) of drug candidates. In particular,  the  developed and refined algorithms and the obtained experimental information will be exploited in the search of discovering the first generation of drugs inhibiting the formation of «off-pathway oligomers», which are crucial, but still unexplored, therapeutic targets in the molecular protein-related mechanisms associated to several genetic and sporadic neurodegenerative disorders, such as Parkinson’s or Alzheimer’s diseases, among others. This research constitutes a step forward in HTS methodologies, allowing developed algorithms expected to increase the “hit” success rates, detection of false positives and the access to new molecular targets.